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Genomics and Molecular Biology

Cell biology and metabolism is a field of research that examines how cells function and how they produce and use energy to sustain life. Cell biology focuses on the structure, organisation and behaviour of cells, including how they grow, communicate and respond to their environment. Metabolism refers to the complex network of chemical reactions that occur within cells to convert nutrients into energy and essential molecules needed for survival, growth and repair. Together, this area of research helps scientists understand how normal cellular processes maintain health and how disruptions in these processes can contribute to diseases such as cancer, neurological disorders and metabolic conditions.

The Biomolecular Modelling Group employs molecular dynamics simulations alongside a range of computational approaches to investigate the structure, dynamics and interactions of complex biomolecules, including cell membranes, proteins and nucleic acids. Current research focuses on understanding the mechanisms of action of cryoprotective agents, the formation and stabilisation of protocells in studies of the origins of life, and the aggregation processes of amyloidogenic proteins.

The group also undertakes research in protein modelling and the analysis of ligand–protein and protein–protein interactions, with applications in drug discovery and broader biotechnological innovation. In addition, Professor Mancera maintains active research interests in the application of biochemical, bioanalytical and biophysical methods within the field of cryobiotechnology.