Professor John Mamo’s research focuses on the role of cerebral microvascular dysfunction and blood-brain barrier impairment in the development and progression of neurodegenerative and metabolic diseases. His work investigates how vascular health influences brain function, with particular emphasis on conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy and other neurological disorders.

His research integrates molecular biology, physiology, clinical science and translational medicine to better understand disease mechanisms and identify new therapeutic and preventative strategies aimed at improving long-term brain and metabolic health.