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Organoid hub

Advanced technologies for scalable, physiologically relevant drug discovery

Core capabilities include high-content imaging, automated liquid handling, bioprinting and bioreactor-based cell expansion. The platform enables high-throughput, high-resolution assessment of disease biology and therapeutic response in clinically relevant model systems.

Organoid hub

The Western Australian Organoid Innovation Hub (WAOIH) at Curtin MRI integrates advanced technologies for scalable, physiologically relevant drug discovery using organoid and other 3D cell models, including patient-derived models.

Core capabilities include high-content imaging, automated liquid handling, bioprinting and bioreactor-based cell expansion.

The platform enables high-throughput, high-resolution assessment of disease biology and therapeutic response in clinically relevant model systems.

High-content imaging and analysis.

Revvity Operetta CLS:

The Operetta CLS system integrates advanced optics, automation, and analysis tools to maximise data quality and throughput:

  • Wide range of air and water-immersion objectives for enhanced light capture and sensitivity: 5X, 10X, 20X Air Objectives, 20X, 40X, 63X Water Objectives
  • Stable LED illumination with eight excitation wavelengths for flexible multiplexing
  • Confocal and widefield imaging modes
  • Integrated environmental control for live-cell and time-lapse imaging
  • High-throughput capacity supporting formats up to 1536-well plates
  • Integrated automation using Plate::handler™ FlexArm enables fully autonomous imaging workflows. Liconic automated incubator with 44-plate capacity supports long-term experiments.
  • Quantitative, multiparametric data at single-cell resolution using Revvity Harmony software, or export images to integrate with analysis software of your choice
Product information
Information on harmony software

Revvity VICTOR Nivo:

  • The VICTOR Nivo Multimode Plate Reader, integrated with an automated plate stacker enables multimode detection. Capabilities include:
    • Fluorescence, UV/Vis Absorbance and Luminescence
    • Reading across plate formats from 1 to 1536 wells
    • Integrated plate stacker (up to 20 plates) for walk-away operation
    • Temperature control up to 65 °C and plate shaker:
Product information

Liquid Handling

 

Zephyr G3 NGS Liquid Handling Workstation:

The Zephyr G3 NGS Workstation enables compact, high-precision automated liquid handling.

  • High-precision automation with a 96-channel pipetting head and integrated gripper for reliable, reproducible processing
  • Integrated deck capabilities including temperature control, shaking, and automated tip waste handling

 

INTEGRA VIAFLO 384 electronic pipetting system:

The INTEGRA VIAFLO 384 enables rapid, precise liquid handling for high-throughput plate formats, supporting efficient assay setup and plate replication.

  • Flexible multichannel formats with interchangeable heads: 96-channel (50 µL, 300 µL) and 384-channel (125 µL) for rapid processing across plate densities
  • High precision and reproducibility through electronic control, reducing variability in dispensing and improving assay consistency
Product information

3D cell and model production

CELLINK BIO X6 bioprinter:

The CELLINK BIO X6 supports multi-material 3D bioprinting for generation of structured cell and tissue models.

  • Configurable printheads (pneumatic, temperature-controlled, syringe-based) for handling a range of bioink viscosities and materials
  • Enclosed, controlled printing conditions with integrated multi-wavelength photocuring, HEPA filtration, and temperature-regulated print bed
Product information

Inventia RASTRUM Bioprinter:

The Inventia RASTRUM enables reproducible, plate-based fabrication of 3D cell cultures for downstream assays.

  • Drop-on-demand deposition for controlled placement of cells and hydrogels in standard multiwell formats
  • Production of 3D cultures compatible with screening and imaging workflows
Product information

CERO 3D Incubator and Bioreactor

CERO 3D Incubator and Bioreactor enables scalable, low-shear 3D culture of organoids and spheroids in a controlled, physiologically relevant environment.

  • Dynamic suspension culture using bi-directional rotation to improve viability, structure, and reproducibility
  • Automated environmental control (temperature, CO₂) for stable long-term culture
Product information
_BCC2209_CERO

Organoid hub gallery

Training and access

All users must complete facility-specific training before gaining independent access to shared research equipment.

Training includes:

  • General induction: Covers fundamental principles, equipment operation and safety protocols.
  • Instrument-specific training: Provides hands-on instruction tailored to each researcher’s specific applications.
  • Refresher and advanced training: Supports ongoing skill development, troubleshooting and safe, effective equipment use.

Bookings and facility use

  • Licensed users have access to online booking systems for equipment scheduling.
  • Contact facility staff for training, troubleshooting, or equipment-specific queries.

Attribution and authorship

All research using Curtin MRI facilities must acknowledge the relevant facility in publications. Where significant intellectual contributions are made by facility staff, authorship should be considered.

Organoid hub contact and support 

For inquiries or feedback contact:

Dr Ben Dwyer
Senior Research Fellow
Email: ben.dwyer@curtin.edu.au
Tel: +61 (08) 9266 2738

Organoid hub virtual tour